Integration of ATP, cAMP, and Ca2+ signals in insulin granule exocytosis.

  title={Integration of ATP, cAMP, and Ca2+ signals in insulin granule exocytosis.},
  author={Tadao Shibasaki and Yasuhiro Sunaga and Susumu Seino},
  volume={53 Suppl 3},
Intracellular ATP, cAMP, and Ca2+ are major signals involved in the regulation of insulin secretion in the pancreatic beta-cell. We recently found that the ATP-sensitive K+ channel (KATP channel) as an ATP sensor, cAMP-GEFII as a cAMP sensor, Piccolo as a Ca2+ sensor, and L-type voltage-dependent Ca2+ channel (VDCC) can interact with each other. In the present study, we examined the effects of cAMP and ATP on the interaction of cAMP-GEFII and sulfonylurea receptor-1 (SUR1). Interaction of cAMP… CONTINUE READING
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MgATP activates the cell FIG. 3. Model of the integration of the ATP, cAMP, and Ca2 signals in insulin granule exocytosis

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