Integration-free induced pluripotent stem cells derived from retinitis pigmentosa patient for disease modeling.

Abstract

We investigated retinitis pigmentosa (RP) caused by a mutation in the gene rhodopsin (RHO) with a patient-specific rod cell model generated from induced pluripotent stem cells (iPSCs) derived from an RP patient. To generate the iPSCs and to avoid the unpredictable side effects associated with retrovirus integration at random loci in the host genome, a… (More)
DOI: 10.5966/sctm.2012-0005

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