Integration and global analysis of isothermal titration calorimetry data for studying macromolecular interactions

@article{Brautigam2016IntegrationAG,
  title={Integration and global analysis of isothermal titration calorimetry data for studying macromolecular interactions},
  author={C. Brautigam and H. Zhao and Carolyn Vargas and S. Keller and P. Schuck},
  journal={Nature Protocols},
  year={2016},
  volume={11},
  pages={882-894}
}
Isothermal titration calorimetry (ITC) is a powerful and widely used method to measure the energetics of macromolecular interactions by recording a thermogram of differential heating power during a titration. [...] Key Method This is performed using the integrated public-domain software packages NITPIC, SEDPHAT and GUSSI. The recently developed low-noise thermogram integration approach and global analysis allow for more precise parameter estimates and more reliable quantification of multisite and multicomponent…Expand
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