Integrating sequence variation and protein structure to identify sites under selection.

@article{Meyer2012IntegratingSV,
  title={Integrating sequence variation and protein structure to identify sites under selection.},
  author={Austin G. Meyer and Claus O. Wilke},
  journal={Molecular biology and evolution},
  year={2012},
  volume={30 1},
  pages={
          36-44
        }
}
We present a novel method to identify sites under selection in protein-coding genes. Our method combines the traditional Goldman-Yang model of coding-sequence evolution with the information obtained from the 3D structure of the evolving protein, specifically the relative solvent accessibility (RSA) of individual residues. We develop a random-effects likelihood sites model in which rate classes are RSA dependent. The RSA dependence is modeled with linear functions. We demonstrate that our RSA… CONTINUE READING

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