Integrating pharmacology and in vivo cancer models in preclinical and clinical drug development.

@article{Peterson2004IntegratingPA,
  title={Integrating pharmacology and in vivo cancer models in preclinical and clinical drug development.},
  author={Jennifer K. Peterson and Peter James Houghton},
  journal={European journal of cancer},
  year={2004},
  volume={40 6},
  pages={837-44}
}
Historically, cancer drug development has been a roller coaster. Numerous agents have shown exciting activity in preclinical models and yet have had minimal activity clinically. These disappointments have led to reasonable scepticism about the true value of both syngeneic and xenograft rodent tumour models in accurately identifying agents that will have important clinical utility. Whereas the development of newer techniques, including transgenic mouse models of cancer, offers the potential to… CONTINUE READING

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