Integrating pharmacogenomics into drug development.

  title={Integrating pharmacogenomics into drug development.},
  author={Ann E. Ferentz},
  volume={3 4},
The first observations of inherited differences in drug effects in the 1950s led to the recognition of a genetic basis for drug response. With the development of genetics and molecular biology, it became clear that certain drug responses could be associated with specific genetic variations or polymorphisms. There are now examples of polymorphisms that affect response to drugs ranging from common analgesics to chemotherapeutics. The goal of pharmacogenetics is to identify polymorphisms that can… CONTINUE READING