Integrating patient and whole-genome sequencing data to provide insights into the epidemiology of seasonal influenza A(H3N2) viruses

@article{Goldstein2018IntegratingPA,
  title={Integrating patient and whole-genome sequencing data to provide insights into the epidemiology of seasonal influenza A(H3N2) viruses},
  author={Emily J. Goldstein and William T. Harvey and Gavin S. Wilkie and S J Shepherd and Alasdair R. Maclean and Pablo Ramiro Murcia and R Gunson},
  journal={Microbial Genomics},
  year={2018},
  volume={4}
}
Genetic surveillance of seasonal influenza is largely focused on sequencing of the haemagglutinin gene. Consequently, our understanding of the contribution of the remaining seven gene segments to the evolution and epidemiological dynamics of seasonal influenza is relatively limited. The increased availability of next-generation sequencing technologies allows rapid and economic whole-genome sequencing (WGS) of influenza virus. Here, 150 influenza A(H3N2) positive clinical specimens with linked… 

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