Integrating one-dimensional and three-dimensional maps of genomes.

  title={Integrating one-dimensional and three-dimensional maps of genomes.},
  author={Natalia Naumova and Job Dekker},
  journal={Journal of cell science},
  volume={123 Pt 12},
Genomes exist in vivo as complex physical structures, and their functional output (i.e. the gene expression profile of a cell) is related to their spatial organization inside the nucleus as well as to local chromatin status. Chromatin modifications and chromosome conformation are distinct in different tissues and cell types, which corresponds closely with the diversity in gene-expression patterns found in different tissues of the body. The biological processes and mechanisms driving these… CONTINUE READING