Integrating oncolytic viruses in combination cancer immunotherapy

  title={Integrating oncolytic viruses in combination cancer immunotherapy},
  author={Praveen K. Bommareddy and Megha Shettigar and Howard L. Kaufman},
  journal={Nature Reviews Immunology},
Oncolytic viruses can be usefully integrated into tumour immunotherapies, as they target multiple steps within the cancer–immunity cycle. Oncolytic viruses directly lyse tumour cells, leading to the release of soluble antigens, danger signals and type I interferons, which drive antitumour immunity. In addition, some oncolytic viruses can be engineered to express therapeutic genes or can functionally alter tumour-associated endothelial cells, further enhancing T cell recruitment into immune… CONTINUE READING

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