Integrating life history and cross-immunity into the evolutionary dynamics of pathogens.

@article{Restif2006IntegratingLH,
  title={Integrating life history and cross-immunity into the evolutionary dynamics of pathogens.},
  author={Olivier Restif and Bryan T. Grenfell},
  journal={Proceedings. Biological sciences},
  year={2006},
  volume={273 1585},
  pages={409-16}
}
Models for the diversity and evolution of pathogens have branched into two main directions: the adaptive dynamics of quantitative life-history traits (notably virulence) and the maintenance and invasion of multiple, antigenically diverse strains that interact with the host's immune memory. In a first attempt to reconcile these two approaches, we developed a simple modelling framework where two strains of pathogens, defined by a pair of life-history traits (infectious period and infectivity… CONTINUE READING

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