Integrating histology and imaging mass spectrometry.

  title={Integrating histology and imaging mass spectrometry.},
  author={P Chaurand and Sarah A. Schwartz and Dean Billheimer and Baogang J. Xu and Anna Crecelius and Richard M Caprioli},
  journal={Analytical chemistry},
  volume={76 4},
MALDI (matrix-assisted laser desorption/ionization) imaging mass spectrometry (IMS) is a new technology that generates molecular profiles and two-dimensional ion density maps of peptide and protein signals directly from the surface of thin tissue sections. This allows specific information to be obtained on the relative abundance and spatial distribution of proteins. One important aspect of this is the opportunity to correlate these specific ion images with histological features observed by… CONTINUE READING


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