Integrating glutathione metabolism and mitochondrial dysfunction with implications for Parkinson’s disease: A dynamic model

@article{Vali2007IntegratingGM,
  title={Integrating glutathione metabolism and mitochondrial dysfunction with implications for Parkinson’s disease: A dynamic model},
  author={Shireen Vali and Rajeswara Babu Mythri and Balusamy Jagatha and Jyothi Padiadpu and Muchukunte Mukunda Srinivas Bharath},
  journal={Neuroscience},
  year={2007},
  volume={149},
  pages={917-930}
}
UNLABELLED Oxidative/nitrosative stress and mitochondrial dysfunction have been implicated in the degeneration of dopaminergic neurons in the substantia nigra during Parkinson's disease (PD). During early stages of PD, there is a significant depletion of the thiol antioxidant glutathione (GSH), which may lead to oxidative stress, mitochondrial dysfunction, and ultimately neuronal cell death. Mitochondrial complex I (CI) is believed to be the central player to the mitochondrial dysfunction… CONTINUE READING
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