Integrating evolutionary and functional approaches to infer adaptation at specific loci.

  title={Integrating evolutionary and functional approaches to infer adaptation at specific loci.},
  author={Jay F Storz and Christopher W Wheat},
  journal={Evolution; international journal of organic evolution},
  volume={64 9},
Inferences about adaptation at specific loci are often exclusively based on the static analysis of DNA sequence variation. Ideally,population-genetic evidence for positive selection serves as a stepping-off point for experimental studies to elucidate the functional significance of the putatively adaptive variation. We argue that inferences about adaptation at specific loci are best achieved by integrating the indirect, retrospective insights provided by population-genetic analyses with the more… CONTINUE READING
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