Integrating developmental signals: a Hippo in the (path)way

  title={Integrating developmental signals: a Hippo in the (path)way},
  author={Alain Mauviel and Flore Nallet-Staub and Xaralabos Varelas},
The Hippo pathway, a signaling cascade that controls cell cycle progression, apoptosis and cell differentiation, has emerged as a fundamental regulator of many physiological and pathological processes. Recent studies have revealed a complex network of interactions directing Hippo pathway activity, and have connected this pathway with other key signaling pathways. Such crosstalk has uncovered novel roles for Hippo signaling, including regulation of TGFβ/SMAD and WNT/β-catenin pathways. This… CONTINUE READING