Integrating conflicting chemotactic signals. The role of memory in leukocyte navigation.

@article{Foxman1999IntegratingCC,
  title={Integrating conflicting chemotactic signals. The role of memory in leukocyte navigation.},
  author={E. Foxman and E. Kunkel and E. Butcher},
  journal={Journal of Cell Biology},
  year={1999},
  volume={147},
  pages={577-588}
}
Leukocytes navigate through complex chemoattractant arrays, and in so doing, they must migrate from one chemoattractant source to another. By evaluating directional persistence and chemotaxis during neutrophil migration under agarose, we show that cells migrating away from a local chemoattractant, against a gradient, display true chemotaxis to distant agonists, often behaving as if the local gradient were without effect. We describe two interrelated properties of migrating cells that allow this… Expand

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