Integrating chromosomal aberrations and gene expression profiles to dissect rectal tumorigenesis

@article{Lips2008IntegratingCA,
  title={Integrating chromosomal aberrations and gene expression profiles to dissect rectal tumorigenesis},
  author={Esther H. Lips and Ronald van Eijk and Eelco J. R. de Graaf and Jan Oosting and Noel F C C de Miranda and Thomas Karsten and Cornelis J. H. van de Velde and Paul H. C. Eilers and Rob A. E. M. Tollenaar and Tom van Wezel and Hans M. Morreau},
  journal={BMC Cancer},
  year={2008},
  volume={8},
  pages={314 - 314}
}
Accurate staging of rectal tumors is essential for making the correct treatment choice. In a previous study, we found that loss of 17p, 18q and gain of 8q, 13q and 20q could distinguish adenoma from carcinoma tissue and that gain of 1q was related to lymph node metastasis. In order to find markers for tumor staging, we searched for candidate genes on these specific chromosomes. We performed gene expression microarray analysis on 79 rectal tumors and integrated these data with genomic data from… CONTINUE READING