Integrating cell-signalling pathways with NF-κB and IKK function

@article{Perkins2007IntegratingCP,
  title={Integrating cell-signalling pathways with NF-$\kappa$B and IKK function},
  author={Neil D Perkins},
  journal={Nature Reviews Molecular Cell Biology},
  year={2007},
  volume={8},
  pages={49-62}
}
  • N. Perkins
  • Published 2007
  • Biology
  • Nature Reviews Molecular Cell Biology
Nuclear factor (NF)-κB and inhibitor of NF-κB kinase (IKK) proteins regulate many physiological processes, including the innate- and adaptive-immune responses, cell death and inflammation. Disruption of NF-κB or IKK function contributes to many human diseases, including cancer. However, the NF-κB and IKK pathways do not exist in isolation and there are many mechanisms that integrate their activity with other cell-signalling networks. This crosstalk constitutes a decision-making process that… 
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References

SHOWING 1-10 OF 146 REFERENCES
Ubiquitin signalling in the NF-κB pathway
TLDR
Several enzymes involved in the ubiquitination and deubiquitination of signalling proteins that mediate IKK activation through a degradation-independent mechanism are revealed.
IKK/NF-κB signaling: balancing life and death – a new approach to cancer therapy
TLDR
Inhibition of IKK-driven NF-kappaB activation offers a strategy for treatment of different malignancies and can convert inflammation- induced tumor growth to inflammation-induced tumor regression.
Shaping the nuclear action of NF-κB
The NF-κB/REL family of transcription factors pivotally control the inflammatory and immune responses, as well as other genetic programmes that are central to cell growth and survival. The…
The IKK/NF-κB activation pathway—a target for prevention and treatment of cancer
Activators and target genes of Rel/NF-κB transcription factors
TLDR
It is argued that NF-κB functions more generally as a central regulator of stress responses and pairing stress responsiveness and anti-apoptotic pathways through the use of a common transcription factor may result in increased cell survival following stress insults.
Interactions of NF-κB with chromatin: the art of being at the right place at the right time
TLDR
It is becoming increasingly apparent that in addition to this required activation step, both recruitment of NF-κB to target genes and NF-σκB-induced transcriptional events after recruitment are actively controlled.
The tumour suppressor CYLD negatively regulates NF-κB signalling by deubiquitination
TLDR
CYLD, a tumour suppressor that is mutated in familial cylindromatosis, interacts with NEMO, the regulatory subunit of IKK, strengthening the notion that ubiquitination is involved in IKK activation by TRAFs and suggesting that CYLD functions in this process.
The NF-κB-mediated control of the JNK cascade in the antagonism of programmed cell death in health and disease
TLDR
It is shown that further delineating the mechanisms by which NF-κB promotes cell survival might hold the key to developing new highly effective therapies for treatment of widespread human diseases.
The two NF-κB activation pathways and their role in innate and adaptive immunity
NF-κB Is Essential for Induction of CYLD, the Negative Regulator of NF-κB
TLDR
A novel autoregulatory feedback pathway through which activation of NF-κB by TNF-α and bacterium nontypeable Haemophilus influenzae (NTHi) induces CYLD that in turn leads to the negative regulation of NF -κB signaling is revealed.
...
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