Integrating cell-signalling pathways with NF-κB and IKK function

  title={Integrating cell-signalling pathways with NF-$\kappa$B and IKK function},
  author={Neil D Perkins},
  journal={Nature Reviews Molecular Cell Biology},
  • N. Perkins
  • Published 2007
  • Biology
  • Nature Reviews Molecular Cell Biology
Nuclear factor (NF)-κB and inhibitor of NF-κB kinase (IKK) proteins regulate many physiological processes, including the innate- and adaptive-immune responses, cell death and inflammation. Disruption of NF-κB or IKK function contributes to many human diseases, including cancer. However, the NF-κB and IKK pathways do not exist in isolation and there are many mechanisms that integrate their activity with other cell-signalling networks. This crosstalk constitutes a decision-making process that… 
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