Integrating cell-cycle progression, drug penetration and energy metabolism to identify improved cancer therapeutic strategies.


The effectiveness of chemotherapeutic drugs in tumors is reduced by multiple effects including drug diffusion and variable susceptibility of local cell populations. We hypothesized that quantifying the interactions between drugs and tumor microenvironments could be used to identify more effective anti-cancer strategies. To test this hypothesis we created a… (More)
DOI: 10.1016/j.jtbi.2008.02.016


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