Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come?

Abstract

Cardiotoxicity is a severe side effect of drugs that induce structural or electrophysiological changes in heart muscle cells. As a result, the heart undergoes failure and potentially lethal arrhythmias. It is still a major reason for drug failure in preclinical and clinical phases of drug discovery. Current methods for predicting cardiotoxicity are based on… (More)
DOI: 10.1111/bph.13577

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Cite this paper

@inproceedings{Sala2017IntegratingCF, title={Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come?}, author={Luca Sala and Milena Bellin and Christine L Mummery}, booktitle={British journal of pharmacology}, year={2017} }