Integrating adenovirus-adeno-associated virus hybrid vectors devoid of all viral genes.

  title={Integrating adenovirus-adeno-associated virus hybrid vectors devoid of all viral genes.},
  author={Andr{\'e} Lieber and Dirk S. Steinwaerder and Cheryl A. Carlson and Mark A. Kay},
  journal={Journal of virology},
  volume={73 11},
Recently, we demonstrated that inverted repeat sequences inserted into first-generation adenovirus (Ad) vector genomes mediate precise genomic rearrangements resulting in vector genomes devoid of all viral genes that are efficiently packaged into functional Ad capsids. As a specific application of this finding, we generated adenovirus-adeno-associated virus (AAV) hybrid vectors, first-generation Ad vectors containing AAV inverted terminal repeat sequences (ITRs) flanking a reporter gene… CONTINUE READING


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