Integrating a Large Next-Generation Sequencing Panel into the Clinical Diagnosis of Gliomas Provides a Comprehensive Platform for Classification from FFPE Tissue or Smear Preparations.

@article{Parilla2019IntegratingAL,
  title={Integrating a Large Next-Generation Sequencing Panel into the Clinical Diagnosis of Gliomas Provides a Comprehensive Platform for Classification from FFPE Tissue or Smear Preparations.},
  author={Megan Parilla and Sabah Kadri and Sushant A. Patil and Carrie Fitzpatrick and Lauren L Ritterhouse and Jeremy P. Segal and John Raymond Collins and Peter Pytel},
  journal={Journal of neuropathology and experimental neurology},
  year={2019}
}
The 2016 WHO classification of brain tumors represents a major step towards the integration of molecular data into pathologic diagnoses. Our institution has included massively parallel sequencing technology in the diagnostic work-up of all gliomas since January 2016. The utilized platform successfully identifies copy number variations, individual gene mutations, small insertions and deletions, and selected gene fusions. Herein, we retrospectively review the first 51 glial tumor samples run for… CONTINUE READING
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