Integrating Patterning Signals: Wnt/GSK3 Regulates the Duration of the BMP/Smad1 Signal

@article{Fuentealba2007IntegratingPS,
  title={Integrating Patterning Signals: Wnt/GSK3 Regulates the Duration of the BMP/Smad1 Signal},
  author={Luis C. Fuentealba and Edward Eivers and Atsushi Ikeda and Cecilia Hurtado and Hiroki Kuroda and Edgar M Pera and Edward M. De Robertis},
  journal={Cell},
  year={2007},
  volume={131},
  pages={980-993}
}
BMP receptors determine the intensity of BMP signals via Smad1 C-terminal phosphorylations. Here we show that a finely controlled cell biological pathway terminates this activity. The duration of the activated pSmad1(Cter) signal was regulated by sequential Smad1 linker region phosphorylations at conserved MAPK and GSK3 sites required for its polyubiquitinylation and transport to the centrosome. Proteasomal degradation of activated Smad1 and total polyubiquitinated proteins took place in the… CONTINUE READING
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