Integrating Myc and TGF-β signalling in cell-cycle control


Expression of the cell cycle inhibitor p15INK4b is suppressed by the Myc oncoprotein and induced by transforming growth factor-β (TGF-β). The transcription factor Miz-1 activates the Ink4b promoter, and interacts with Myc and TGF-β-activated Smad proteins. Miz-1 is thus a point of convergence for these antagonistic signals in cell-cycle control. 
DOI: 10.1038/35074634


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@article{Amati2001IntegratingMA, title={Integrating Myc and TGF-β signalling in cell-cycle control}, author={Bruno Amati}, journal={Nature Cell Biology}, year={2001}, volume={3}, pages={E112-E113} }