Integrating Ion Mobility Mass Spectrometry with Molecular Modelling to Determine the Architecture of Multiprotein Complexes

@inproceedings{Politis2010IntegratingIM,
  title={Integrating Ion Mobility Mass Spectrometry with Molecular Modelling to Determine the Architecture of Multiprotein Complexes},
  author={Argyris Politis and Ah Young Park and Suk-Joon Hyung and Daniel Barsky and Brandon T Ruotolo and Carol V Robinson},
  booktitle={PloS one},
  year={2010}
}
Current challenges in the field of structural genomics point to the need for new tools and technologies for obtaining structures of macromolecular protein complexes. Here, we present an integrative computational method that uses molecular modelling, ion mobility-mass spectrometry (IM-MS) and incomplete atomic structures, usually from X-ray crystallography… CONTINUE READING