Integrating Genetic and Network Analysis to Characterize Genes Related to Mouse Weight

  title={Integrating Genetic and Network Analysis to Characterize Genes Related to Mouse Weight},
  author={Anatole Ghazalpour and Sudheer Doss and Bin Zhang and Susanna S. Wang and Christopher Plaisier and Ruth Castellanos and Alec Brozell and Eric E. Schadt and Thomas A. Drake and Aldons J. Lusis and Steve Horvath},
  journal={PLoS Genetics},
  pages={S103 - S109}
Systems biology approaches that are based on the genetics of gene expression have been fruitful in identifying genetic regulatory loci related to complex traits. We use microarray and genetic marker data from an F2 mouse intercross to examine the large-scale organization of the gene co-expression network in liver, and annotate several gene modules in terms of 22 physiological traits. We identify chromosomal loci (referred to as module quantitative trait loci, mQTL) that perturb the modules and… CONTINUE READING
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