Integrating Experimental and Analytic Approaches to Improve Data Quality in Genome-wide RNAi Screens

@article{Zhang2008IntegratingEA,
  title={Integrating Experimental and Analytic Approaches to Improve Data Quality in Genome-wide RNAi Screens},
  author={Xiaohua Douglas Zhang and Amy S. Espeseth and Eric N. Johnson and Jayne Chin and Adam T. Gates and Lyndon J. Mitnaul and Shane D. Marine and Jenny Tian and Erica M. Stec and Priya Kunapuli and Daniel J. Holder and Joseph F. Heyse and Berta Strulovici and Marc Ferrer},
  journal={Journal of Biomolecular Screening},
  year={2008},
  volume={13},
  pages={378 - 389}
}
RNA interference (RNAi) not only plays an important role in drug discovery but can also be developed directly into drugs. RNAi high-throughput screening (HTS) biotechnology allows us to conduct genome-wide RNAi research. A central challenge in genome-wide RNAi research is to integrate both experimental and computational approaches to obtain high quality RNAi HTS assays. Based on our daily practice in RNAi HTS experiments, we propose the implementation of 3 experimental and analytic processes to… 

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