Integrating Biological Knowledge with Gene Expression Profiles for Survival Prediction of Cancer

@article{Chen2009IntegratingBK,
  title={Integrating Biological Knowledge with Gene Expression Profiles for Survival Prediction of Cancer},
  author={Xi Chen and Lily Wang},
  journal={Journal of computational biology : a journal of computational molecular cell biology},
  year={2009},
  volume={16 2},
  pages={265-78}
}
Due to the large variability in survival times between cancer patients and the plethora of genes on microarrays unrelated to outcome, building accurate prediction models that are easy to interpret remains a challenge. In this paper, we propose a general strategy for improving performance and interpretability of prediction models by integrating gene expression data with prior biological knowledge. First, we link gene identifiers in expression dataset with gene annotation databases such as Gene… CONTINUE READING