Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes: molecular insight into sex-specific processes and translational repression

@inproceedings{Lasonder2016IntegratedTA,
  title={Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes: molecular insight into sex-specific processes and translational repression},
  author={Edwin Lasonder and Sanna R. Rijpma and Ben C. L. van Schaijk and Wieteke Anna Maria Hoeijmakers and Philip Reiner Kensche and Mark S Gresnigt and Annet Italiaander and Martijn W. Vos and Rob M Woestenenk and Teun Bousema and Gunnar R Mair and Shahid M Khan and Chris J Janse and Rich{\'a}rd B{\'a}rtfai and Robert W. Sauerwein},
  booktitle={Nucleic acids research},
  year={2016}
}
Sexual differentiation of malaria parasites into gametocytes in the vertebrate host and subsequent gamete fertilization in mosquitoes is essential for the spreading of the disease. The molecular processes orchestrating these transitions are far from fully understood. Here, we report the first transcriptome analysis of male and female Plasmodium falciparum gametocytes coupled with a comprehensive proteome analysis. In male gametocytes there is an enrichment of proteins involved in the formation… CONTINUE READING
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