Integrated transcriptional and proteomic analysis with in vitro biochemical assay reveal the important role of CYP3A46 in T-2 toxin hydroxylation in porcine primary hepatocytes.

@article{Wang2011IntegratedTA,
  title={Integrated transcriptional and proteomic analysis with in vitro biochemical assay reveal the important role of CYP3A46 in T-2 toxin hydroxylation in porcine primary hepatocytes.},
  author={Jianshe Wang and Jun Jiang and Hongxia Zhang and Junping Wang and Hua Cai and Cheng Li and Kangbai Li and Jing Liu and Xuejiang Guo and Guangxun Zou and Dazhi Wang and Yiqun Deng and Jiayin Dai},
  journal={Molecular & cellular proteomics : MCP},
  year={2011},
  volume={10 9},
  pages={
          M111.008748
        }
}
Both T-2 toxin and its metabolites are highly potent mycotoxins that can cause severe human and animal diseases upon exposure. Understanding the toxic mechanism and biotransformation process of T-2 toxin at a cellular level is essential for the development of counter-measures. We investigated the effect of T-2 toxin in porcine primary hepatocytes using porcine genome array and two-dimensional difference gel electrophoresis with matrix-assisted laser desorption/ionization tandem time of flight… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 21 CITATIONS

Similar Papers

Loading similar papers…