Integrated systems analysis reveals a molecular network underlying autism spectrum disorders

@inproceedings{Li2014IntegratedSA,
  title={Integrated systems analysis reveals a molecular network underlying autism spectrum disorders},
  author={Jingjing Li and Minyi Shi and Zhihai Ma and Shuchun Zhao and Ghia M Euskirchen and Jennifer L. Ziskin and Alexander Urban and Joachim F. Hallmayer and Michael Snyder},
  booktitle={Molecular systems biology},
  year={2014}
}
Autism is a complex disease whose etiology remains elusive. We integrated previously and newly generated data and developed a systems framework involving the interactome, gene expression and genome sequencing to identify a protein interaction module with members strongly enriched for autism candidate genes. Sequencing of 25 patients confirmed the involvement of this module in autism, which was subsequently validated using an independent cohort of over 500 patients. Expression of this module was… CONTINUE READING
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