Integrated signaling in developing lymphocytes: the role of DNA damage responses.

  title={Integrated signaling in developing lymphocytes: the role of DNA damage responses.},
  author={Jeffrey J. Bednarski and Barry P Sleckman},
  journal={Cell cycle},
  volume={11 22},
Lymphocyte development occurs in a stepwise progression through distinct developmental stages. This ordered maturation ensures that cells express a single, non-autoreactive antigen receptor, which is the cornerstone of a diverse adaptive immune response. Expression of a mature antigen receptor requires assembly of the antigen receptor genes by the process of V(D)J recombination, a reaction that joins distant gene segments through DNA double-strand break (DSB) intermediates. These physiologic… CONTINUE READING


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