Integrated signaling in developing lymphocytes: the role of DNA damage responses.


Lymphocyte development occurs in a stepwise progression through distinct developmental stages. This ordered maturation ensures that cells express a single, non-autoreactive antigen receptor, which is the cornerstone of a diverse adaptive immune response. Expression of a mature antigen receptor requires assembly of the antigen receptor genes by the process… (More)
DOI: 10.4161/cc.22021


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