Integrated process optimization: lessons from retrovirus and virus-like particle production.

@article{Cruz2002IntegratedPO,
  title={Integrated process optimization: lessons from retrovirus and virus-like particle production.},
  author={Pedro Estilita Cruz and Luis Maranga and Manuel J. T. Carrondo},
  journal={Journal of biotechnology},
  year={2002},
  volume={99 3},
  pages={199-214}
}
The optimization of production and purification processes is usually approached by engineers from a strictly biotechnological point of view. The present paper envisages the definition and application of an optimization model that takes into account the impact of both biological and technological issues upon the optimization protocols and strategies. For this purpose, the optimization of three analogous but different systems comprising animal cell growth and bioparticle production is presented… CONTINUE READING