Integrated platform for functional monitoring of biomimetic heart sheets derived from human pluripotent stem cells.

@article{Chen2014IntegratedPF,
  title={Integrated platform for functional monitoring of biomimetic heart sheets derived from human pluripotent stem cells.},
  author={Aaron Chih-Hao Chen and Eugene Lee and Roger Tu and Kevin De Santiago and Anna Grosberg and Charless C. Fowlkes and Michelle Khine},
  journal={Biomaterials},
  year={2014},
  volume={35 2},
  pages={
          675-83
        }
}
We present an integrated platform comprised of a biomimetic substrate and physiologically aligned human pluripotent stem cell-derived cardiomyocytes (CMs) with optical detection and algorithms to monitor subtle changes in cardiac properties under various conditions. In the native heart, anisotropic tissue structures facilitate important concerted mechanical contraction and electrical propagation. To recapitulate the architecture necessary for a physiologically accurate heart response, we have… CONTINUE READING

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