Integrated network analysis identifies nitric oxide response networks and dihydroxyacid dehydratase as a crucial target in Escherichia coli.

@article{Hyduke2007IntegratedNA,
  title={Integrated network analysis identifies nitric oxide response networks and dihydroxyacid dehydratase as a crucial target in Escherichia coli.},
  author={Daniel R. Hyduke and Laura R. Jarboe and Linh M. Tran and Katherine J Chou and James C. Liao},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 20},
  pages={
          8484-9
        }
}
Nitric oxide (NO) is used by mammalian immune systems to counter microbial invasions and is produced by bacteria during denitrification. As a defense, microorganisms possess a complex network to cope with NO. Here we report a combined transcriptomic, chemical, and phenotypic approach to identify direct NO targets and construct the biochemical response network. In particular, network component analysis was used to identify transcription factors that are perturbed by NO. Such information was… CONTINUE READING

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