Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling.

@article{Kristensen2012IntegratedMP,
  title={Integrated molecular profiles of invasive breast tumors and ductal carcinoma in situ (DCIS) reveal differential vascular and interleukin signaling.},
  author={Vessela N. Kristensen and Charles J. Vaske and Josie Ursini-Siegel and Peter Van Loo and Silje H. Nordgard and Ravi Sachidanandam and Th{\'e}rese S\orlie and Fredrik W{\"a}rnberg and Vilde Drageset Haakensen and {\AA}slaug Helland and Bj\orn Naume and Charles M. Perou and David Haussler and Olga G. Troyanskaya and Anne-Lise B\orresen-Dale},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 8},
  pages={2802-7}
}
We use an integrated approach to understand breast cancer heterogeneity by modeling mRNA, copy number alterations, microRNAs, and methylation in a pathway context utilizing the pathway recognition algorithm using data integration on genomic models (PARADIGM). We demonstrate that combining mRNA expression and DNA copy number classified the patients in groups that provide the best predictive value with respect to prognosis and identified key molecular and stromal signatures. A chronic… CONTINUE READING
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