Integrated models for the prediction of late genitourinary complaints after high-dose intensity modulated radiotherapy for prostate cancer: making informed decisions.

@article{Langhe2014IntegratedMF,
  title={Integrated models for the prediction of late genitourinary complaints after high-dose intensity modulated radiotherapy for prostate cancer: making informed decisions.},
  author={Sofie De Langhe and Gert O De Meerleer and Kim De Ruyck and Piet Ost and Val{\'e}rie Fonteyne and Wilfried De Neve and Hubert Thierens},
  journal={Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology},
  year={2014},
  volume={112 1},
  pages={95-9}
}
BACKGROUND AND PURPOSE To develop predictive models for late radiation-induced hematuria and nocturia allowing a patient individualized estimation of pre-treatment risk. MATERIALS AND METHODS We studied 262 PCa patients treated with curative intensity modulated radiotherapy to the intact prostate or prostate bed. A total of 372 variables were used for prediction modeling, among which 343 genetic variations. Toxicity was scored using an in-house developed toxicity scale. Predictor selection is… CONTINUE READING

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