Integrated modeling of the major events in the MHC class I antigen processing pathway.

@article{Dnnes2005IntegratedMO,
  title={Integrated modeling of the major events in the MHC class I antigen processing pathway.},
  author={Pierre D{\"o}nnes and Oliver Kohlbacher},
  journal={Protein science : a publication of the Protein Society},
  year={2005},
  volume={14 8},
  pages={2132-40}
}
Rational design of epitope-driven vaccines is a key goal of immunoinformatics. Typically, candidate selection relies on the prediction of MHC-peptide binding only, as this is known to be the most selective step in the MHC class I antigen processing pathway. However, proteasomal cleavage and transport by the transporter associated with antigen processing (TAP) are essential steps in antigen processing as well. While prediction methods exist for the individual steps, no method has yet offered an… CONTINUE READING