Integrated model for denosumab and ibandronate pharmacodynamics in postmenopausal women.

@article{Marathe2011IntegratedMF,
  title={Integrated model for denosumab and ibandronate pharmacodynamics in postmenopausal women.},
  author={Dhananjay D. Marathe and Anshu Marathe and Donald E Mager},
  journal={Biopharmaceutics & drug disposition},
  year={2011},
  volume={32 8},
  pages={471-81}
}
This study aims to characterize the pharmacodynamic properties of denosumab, a RANK ligand inhibitor, and ibandronate, a bisphosphonate, using an integrated bone homeostasis model in postmenopausal women. Mean temporal profiles of denosumab, serum and urine N-telopeptide (sNTX, uNTX), lumbar spine bone mineral density (BMD) following denosumab administration, and urine C-telopeptide (uCTX) and lumbar spine BMD upon ibandronate administration were extracted from the literature. A mechanistic… CONTINUE READING
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611–635

  • JuskoWJ. Characterization of four basic models of indirect Sharma A, 24
  • Biopharm. Drug Dispos. 32: 471–481
  • 2011
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