Integrated kinetics of X chromosome inactivation in differentiating embryonic stem cells

  title={Integrated kinetics of X chromosome inactivation in differentiating embryonic stem cells},
  author={Julie Chaumeil and Ikuhiro Okamoto and Mich{\`e}le Guggiari and Edith Heard},
  journal={Cytogenetic and Genome Research},
  pages={75 - 84}
Inactivation of the X chromosome during early female development and the subsequent maintenance of this transcriptionally inert state through countless cell divisions remain a paradigm for epigenetic regulation in mammals. Nevertheless, the exact mechanisms underlying this chromosome-wide silencing process remain unclear. Using differentiating female embryonic stem (ES) cells as a model system, we recently found that histone H3 tail modifications are among the earliest known chromatin changes… 

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