Integrated kinetics of X chromosome inactivation in differentiating embryonic stem cells

  title={Integrated kinetics of X chromosome inactivation in differentiating embryonic stem cells},
  author={J. Chaumeil and I. Okamoto and M. Guggiari and E. Heard},
  journal={Cytogenetic and Genome Research},
  pages={75 - 84}
  • J. Chaumeil, I. Okamoto, +1 author E. Heard
  • Published 2002
  • Medicine, Biology
  • Cytogenetic and Genome Research
  • Inactivation of the X chromosome during early female development and the subsequent maintenance of this transcriptionally inert state through countless cell divisions remain a paradigm for epigenetic regulation in mammals. Nevertheless, the exact mechanisms underlying this chromosome-wide silencing process remain unclear. Using differentiating female embryonic stem (ES) cells as a model system, we recently found that histone H3 tail modifications are among the earliest known chromatin changes… CONTINUE READING
    96 Citations
    High-resolution analysis of epigenetic changes associated with X inactivation.
    • 134
    • PDF
    The Implication of Early Chromatin Changes in X Chromosome Inactivation
    • 63
    Recent advances in X-chromosome inactivation.
    • E. Heard
    • Biology, Medicine
    • Current opinion in cell biology
    • 2004
    • 293
    • PDF
    Dynamic changes in paternal X-chromosome activity during imprinted X-chromosome inactivation in mice
    • 148
    • PDF
    ConteXt of change—X inactivation and disease
    • 28
    • PDF
    Evolutionary diversity and developmental regulation of X-chromosome inactivation
    • 89
    • PDF
    Establishment of X chromosome inactivation and epigenomic features of the inactive X depend on cellular contexts
    • 20


    X-Inactivation and histone H4 acetylation in embryonic stem cells.
    • 254
    • Highly Influential
    • PDF
    Xist RNA and the mechanism of X chromosome inactivation.
    • 414
    • PDF
    Histone H3 Lysine 9 Methylation Occurs Rapidly at the Onset of Random X Chromosome Inactivation
    • 173
    • Highly Influential
    • PDF
    Imprinted X inactivation maintained by a mouse Polycomb group gene
    • 316
    Correlation between X-chromosome inactivation and cell differentiation in female preimplantation mouse embryos.
    • 44
    Methylation of the Hprt gene on the inactive X occurs after chromosome inactivation
    • 337
    Methylation of Histone H3 at Lys-9 Is an Early Mark on the X Chromosome during X Inactivation
    • 498