Integrated hemodynamic, hormonal, and renal actions of urocortin 2 in normal and paced sheep: beneficial effects in heart failure.

@article{Rademaker2005IntegratedHH,
  title={Integrated hemodynamic, hormonal, and renal actions of urocortin 2 in normal and paced sheep: beneficial effects in heart failure.},
  author={Miriam Tessa Rademaker and Vicky A. Cameron and Christopher John Charles and Arthur Mark Richards},
  journal={Circulation},
  year={2005},
  volume={112 23},
  pages={
          3624-32
        }
}
BACKGROUND Urocortin 2 (Ucn2) has potent cardiovascular actions and may participate in the pathophysiology of heart failure (HF). The integrated hemodynamic, endocrine, and renal effects of Ucn2 are unknown. METHODS AND RESULTS Eight sheep received incremental intravenous boluses of murine Ucn2 (10, 50, and 100 microg at 2-hour intervals) before (normal) and during pacing-induced HF. Compared with control data, Ucn2 induced rapid and dose-dependent increases in cardiac output (peak effects… CONTINUE READING
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Integrated hemodynamic , hormonal and renal actions of urocortin 2 in normal and paced sheep : beneficial effects in heart failure

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