Integrated genomic study of quadruple-WT GIST (KIT/PDGFRA/SDH/RAS pathway wild-type GIST)

@inproceedings{Nannini2014IntegratedGS,
  title={Integrated genomic study of quadruple-WT GIST (KIT/PDGFRA/SDH/RAS pathway wild-type GIST)},
  author={Margherita Nannini and Annalisa Astolfi and Milena Urbini and Valentina Indio and Donatella Santini and Michael C Heinrich and Christopher L. Corless and Claudio Ceccarelli and Maristella Saponara and Anna Mandrioli and Cristian Lolli and Giorgio Ercolani and Giovanni Brandi and Guido Biasco and Maria Abbondanza Pantaleo},
  booktitle={BMC Cancer},
  year={2014}
}
BackgroundAbout 10-15% of adult gastrointestinal stromal tumors (GIST) and the vast majority of pediatric GIST do not harbour KIT or platelet-derived growth factor receptor alpha (PDGFRA) mutations (J Clin Oncol 22:3813–3825, 2004; Hematol Oncol Clin North Am 23:15–34, 2009). The molecular biology of these GIST, originally defined as KIT/PDGFRA wild-type (WT), is complex due to the existence of different subgroups with distinct molecular hallmarks, including defects in the succinate… CONTINUE READING

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