Integrated genomic profiling identifies two distinct molecular subtypes with divergent outcome in neuroblastoma with loss of chromosome 11q

Abstract

Imbalances in chromosome 11q occur in approximately 30% of primary neuroblastoma and are associated with poor outcome. It has been suggested that 11q loss constitutes a distinct clinico-genetic neuroblastoma subgroup by affecting expression levels of corresponding genes. This study analysed the relationship of 11q loss, clinical phenotype and global… (More)
DOI: 10.1038/onc.2009.390

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@article{Fischer2010IntegratedGP, title={Integrated genomic profiling identifies two distinct molecular subtypes with divergent outcome in neuroblastoma with loss of chromosome 11q}, author={Matthias Fischer and Thomas K. Bauer and Andr{\'e} Oberthuer and Barbara Hero and Jessica Thei\ssen and Mathias Ehrich and Ruediger Spitz and Roland Eils and Frank Westermann and Benedikt Brors and Regina K{\"{o}nig and Frank Berthold}, journal={Oncogene}, year={2010}, volume={29}, pages={865-875} }