Integrated genomic characterization of endometrial carcinoma

@article{Levine2013IntegratedGC,
  title={Integrated genomic characterization of endometrial carcinoma},
  author={D. Levine and L GadStaceyB.KristianEricAndreyCarrieMikeCyriacGetzGabrielCibulskisLanderSivachenkoSougnez and G. Getz and S. Gabriel and K. Cibulskis and E. Lander and A. Sivachenko and C. Sougnez and Mike S Lawrence and C. Kandoth and D. Dooling and R. Fulton and L. Fulton and Joelle M. Kalicki-Veizer and M. McLellan and M. O'Laughlin and Heather K. Schmidt and Richard K. Wilson and K. Ye and L. Ding and E. Mardis and Adrian Ally and Miruna Balasundaram and I. Birol and Y. Butterfield and R. Carlsen and Candace D. Carter and Andy Chu and Eric Chuah and Hye-Jung E. Chun and Noreen Dhalla and R. Guin and Carrie Hirst and R. Holt and Steven J. M. Jones and Darlene Lee and Haiyan I. Li and M. Marra and Michael Mayo and Richard A. Moore and A. Mungall and Patrick Plettner and J. Schein and Payal Sipahimalani and Angela Tam and R. Varhol and A. Gordon Robertson and A. Cherniack and I. Pashtan and G. Saksena and R. Onofrio and Steven E Schumacher and B. Tabak and S. Carter and Bryan Hernandez and Jeff Gentry and H. Salvesen and K. Ardlie and W. Winckler and R. Beroukhim and M. Meyerson and A. Hadjipanayis and Semin Lee and Harshad S. Mahadeshwar and P. Park and A. Protopopov and X. Ren and Sahil Seth and Xingzhi Song and Jiabin Tang and Ruibin Xi and Lixing Yang and Dong Zeng and R. Kucherlapati and L. Chin and Jianhua Zhang and J. Todd Auman and S. Balu and T. Bodenheimer and Elizabeth Buda and D. Neil Hayes and A. Hoyle and S. Jefferys and Corbin D. Jones and S. Meng and P. Mieczkowski and Lisle E. Mose and J. Parker and C. Perou and Jeff Roach and Yan Shi and J. Simons and Mathew G. Soloway and Donghui Tan and M. D. Topal and S. Waring and J. Wu and K. Hoadley and S. Baylin and M. Bootwalla and Phillip H. Lai and Timothy J. Triche and D. J. van den Berg and D. Weisenberger and P. Laird and Hui Shen and Juok Cho and Danielle Dicara and S. Frazer and David Heiman and R. Jing and Pei Lin and William Mallard and P. Stojanov and Douglas Voet and Hailei Zhang and L. Zou and M. Noble and Sheila M. Reynolds and I. Shmulevich and B. Arman Aksoy and Yevgeniy Antipin and G. Ciriello and Gideon Dresdner and J. Gao and Benjamin E. Gross and A. Jacobsen and M. Ladanyi and B. Reva and C. Sander and Rileen Sinha and S. Onur Sumer and B. Taylor and E. Cerami and N. Weinhold and N. Schultz and R. Shen and S. Benz and T. Goldstein and D. Haussler and Sam Ng and C. Szeto and Joshua M. Stuart and C. Benz and C. Yau and Wei Zhang and M. Annala and B. Broom and Tod D. Casasent and Z. Ju and Han Liang and Guoyan Liu and Y. Lu and A. Unruh and C. Wakefield and J. Weinstein and N. Zhang and Yuexin Liu and R. Broaddus and R. Akbani and G. Mills and Christopher Adams and T. Barr and Aaron D. Black and Jay Bowen and John Deardurff and J. Frick and J. Gastier-Foster and T. Grossman and H. Harper and M. Hart-Kothari and Carmen Helsel and Aaron Hobensack and Harkness Kuck and K. Kneile and Kristen M. Leraas and T. Lichtenberg and Cynthia Mcallister and R. Pyatt and N. Ramirez and Teresa R. Tabler and Nathan Vanhoose and P. White and L. Wise and E. Zmuda and N. Barnabas and Charlenia Berry-Green and V. Blanc and L. Boice and Michael Button and {\'A}d{\'a}m Farkas and Alex E. Green and J. Mackenzie and D. Nicholson and S. Kalloger and C. Blake Gilks and B. Karlan and J. Lester and S. Orsulic and M. Borowsky and Mark G. Cadungog and C. Czerwinski and L. Huelsenbeck-Dill and M. Iacocca and N. Petrelli and B. Rabeno and G. Witkin and E. Nemirovich-Danchenko and O. Potapova and D. Rotin and A. Berchuck and M. Birrer and P. Disaia and L. Monovich and Erin E. Curley and Johanna Gardner and D. Mallery and R. Penny and S. Dowdy and B. Winterhoff and Linda N Dao and B. Gostout and A. Meuter and Attila Teoman and F. Dao and Narciso Olvera and F. Bogomolniy and K. Garg and R. Soslow and M. Abramov and J. Bartlett and Sugy Kodeeswaran and J. Parfitt and F. Moiseenko and B. Clarke and M. Goodman and M. Carney and R. Matsuno and J. Fisher and Meijuan Huang and W. Kimryn Rathmell and L. Thorne and L. Van Le and R. Dhir and Robert A. Edwards and E. Elishaev and K. Zorn and P. Goodfellow and D. Mutch and A. Kahn and D. Bell and P. Pollock and Chen Wang and David A.Wheeler and E. Shinbrot and Brenda Ayala and A. Chu and M. Jensen and P. Kothiyal and Todd D. Pihl and J. Pontius and D. Pot and E. Snyder and Deepak Srinivasan and Kenna R. Mills Shaw and Margi Sheth and T. Davidsen and Greg Eley Martin L. Ferguson and John A. Demchok and Liming Yang and M. Guyer and B. Ozenberger and H. Sofia},
  journal={Nature},
  year={2013},
  volume={497},
  pages={67 - 73}
}
  • D. Levine, Gad Stacey B. Kristian Eric Andrey Carrie Mike Cyriac Getz Gabriel Cibulskis Lander Sivachenko Sougnez L, +271 authors H. Sofia
  • Published 2013
  • Biology, Medicine
  • Nature
We performed an integrated genomic, transcriptomic and proteomic characterization of 373 endometrial carcinomas using array- and sequencing-based technologies. Uterine serous tumours and ∼25% of high-grade endometrioid tumours had extensive copy number alterations, few DNA methylation changes, low oestrogen receptor/progesterone receptor levels, and frequent TP53 mutations. Most endometrioid tumours had few copy number alterations or TP53 mutations, but frequent mutations in PTEN, CTNNB1… Expand
Clinicopathologic and Genomic Analysis of TP53-Mutated Endometrial Carcinomas
Molecular characterization of endometrial cancer and therapeutic implications
An integrated molecular profile of endometrioid ovarian cancer.
Chromatin remodelling and DNA repair genes are frequently mutated in endometrioid endometrial carcinoma
Integrated Molecular Characterization of Uterine Carcinosarcoma.
Frequent Homologous Recombination Deficiency in High-grade Endometrial Carcinomas
The genetic landscape of endometrial clear cell carcinomas
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