Integrated genomic analysis of relapsed childhood acute lymphoblastic leukemia reveals therapeutic strategies.

@article{Hogan2011IntegratedGA,
  title={Integrated genomic analysis of relapsed childhood acute lymphoblastic leukemia reveals therapeutic strategies.},
  author={Laura E. Hogan and Julia A. Meyer and Jun Yang and Jinhua Wang and Nicholas C.L. Wong and Wenjian Yang and Gregory Condos and Stephen P Hunger and Elizabeth A. Raetz and Richard Saffery and Mary V. Relling and Deepa Bhojwani and Debra J. Morrison and William L Carroll},
  journal={Blood},
  year={2011},
  volume={118 19},
  pages={5218-26}
}
Despite an increase in survival for children with acute lymphoblastic leukemia (ALL), the outcome after relapse is poor. To understand the genetic events that contribute to relapse and chemoresistance and identify novel targets of therapy, 3 high-throughput assays were used to identify genetic and epigenetic changes at relapse. Using matched diagnosis/relapse bone marrow samples from children with relapsed B-precursor ALL, we evaluated gene expression, copy number abnormalities (CNAs), and DNA… CONTINUE READING
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Ge - nomewide expression analysis of paired diagnosisrelapse samples in ALL indicates involvement of pathways related to DNA replication , cell cycle and DNA repair , independent of immune phenotype

  • FJ Staal, D deRidder, T Szczepanski
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