Integrated genomic analysis of nodular tissue in macronodular adrenocortical hyperplasia: progression of tumorigenesis in a disorder associated with multiple benign lesions.

@article{Almeida2011IntegratedGA,
  title={Integrated genomic analysis of nodular tissue in macronodular adrenocortical hyperplasia: progression of tumorigenesis in a disorder associated with multiple benign lesions.},
  author={Madson Queiroz Almeida and Michelle D. Harran and Eirini I Bimpaki and Hui-Pin Hsiao and Anelia Horvath and Chris Cheadle and Tonya Watkins and Maria Nesterova and Constantine A. Stratakis},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2011},
  volume={96 4},
  pages={E728-38}
}
CONTEXT Massive macronodular adrenocortical disease or ACTH-independent macronodular adrenal hyperplasia (AIMAH) is a clinically and genetically heterogeneous disorder. OBJECTIVE AND DESIGN Whole-genome expression profiling and oligonucleotide array comparative genomic hybridization changes were analyzed in samples of different nodules from the same patients with AIMAH. Quantitative RT-PCR and staining were employed to validate the mRNA array data. RESULTS Chromosomal gains were more… CONTINUE READING