Integrated genome-wide DNA copy number and expression analysis identifies distinct mechanisms of primary chemoresistance in ovarian carcinomas.

@article{Etemadmoghadam2009IntegratedGD,
  title={Integrated genome-wide DNA copy number and expression analysis identifies distinct mechanisms of primary chemoresistance in ovarian carcinomas.},
  author={Dariush Etemadmoghadam and Anna deFazio and Rameen Beroukhim and Craig Mermel and Joshy George and Gad Getz and Richard W. Tothill and Aikou Okamoto and Maria Baroy Raeder and Paul Harnett and Stephen Lade and Lars Andreas Akslen and Anna V. Tinker and Bianca Locandro and Kathryn Alsop and Yoke-Eng Chiew and Nadia Traficante and Si{\'a}n Fereday and Daryl Johnson and Stephen Fox and William Sellers and Mitsuyoshi Urashima and Helga Birgitte Salvesen and Matthew L Meyerson and David Bowtell},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2009},
  volume={15 4},
  pages={1417-27}
}
PURPOSE A significant number of women with serous ovarian cancer are intrinsically refractory to platinum-based treatment. We analyzed somatic DNA copy number variation and gene expression data to identify key mechanisms associated with primary resistance in advanced-stage serous cancers. EXPERIMENTAL DESIGN Genome-wide copy number variation was measured in 118 ovarian tumors using high-resolution oligonucleotide microarrays. A well-defined subset of 85 advanced-stage serous tumors was then… CONTINUE READING
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Analysis of gene amplification and prognostic markers in ovarian cancer using comparative genomic hybridization for microarrays and immunohistochemical analysis for tissue microarrays

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