Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer.

@article{Shen2007IntegratedGA,
  title={Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer.},
  author={Lanlan Shen and Minoru Toyota and Yutaka Kondo and Edward B. Lin and Li Zhang and Yi Guo and Natalie Supunpong Hernandez and Xinli Chen and Saira Ahmed and Kazuo Konishi and Stanley R. Hamilton and Jean-Pierre Issa},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2007},
  volume={104 47},
  pages={
          18654-9
        }
}
Colon cancer has been viewed as the result of progressive accumulation of genetic and epigenetic abnormalities. However, this view does not fully reflect the molecular heterogeneity of the disease. We have analyzed both genetic (mutations of BRAF, KRAS, and p53 and microsatellite instability) and epigenetic alterations (DNA methylation of 27 CpG island promoter regions) in 97 primary colorectal cancer patients. Two clustering analyses on the basis of either epigenetic profiling or a combination… CONTINUE READING

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