Integrated functions for four basic models of indirect pharmacodynamic response.

  title={Integrated functions for four basic models of indirect pharmacodynamic response.},
  author={Wojciech Krzyzanski and William J. Jusko},
  journal={Journal of pharmaceutical sciences},
  volume={87 1},
The integrated solutions (ABEC, area between baseline and effect curve) of four basic models of indirect pharmacodynamic responses are developed. These models assume that drug can inhibit or stimulate the production or loss of the response variable. For two models (I and III) with monoexponential drug disposition, explicit formulas for the ABEC were obtained, where ABEC is a function of ln (1 + (D/V)/IC50) or ln (1 + (D/V)/SC50) where D = dose, V = volume, and IC50 or SC50 = 50% effective… CONTINUE READING

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