Integrated evolutionary, immunological, and neuroendocrine framework for the pathogenesis of chronic disabling inflammatory diseases

  title={Integrated evolutionary, immunological, and neuroendocrine framework for the pathogenesis of chronic disabling inflammatory diseases},
  author={R. Straub and H. Besedovsky},
  journal={The FASEB Journal},
  pages={2176 - 2183}
  • R. Straub, H. Besedovsky
  • Published 2003
  • Biology, Medicine
  • The FASEB Journal
  • The pathogenesis of chronic disabling inflammatory diseases (CDIDs) is poorly understood. Current concepts that focus on abnormalities of the immune system are, in our view, incomplete. Here we propose that chronic disruption of homeostasis through abnormal neuronal and endocrine host re‐ sponses to transient inflammatory reactions contributes to the appearance of CDIDs. Coordinated reactions of the supersystems (immune, nervous, endocrine, and reproductive) that maintain homeostasis have been… CONTINUE READING
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